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There is a debate as to whether the ancillary properties of carvedilol contribute to its beneficial effect in heart failure, making it a better drug to use than metoprolol.
Despite this, β-blockers remain under-prescribed in this condition.
American Society of Echocardiography Committee on Standards on Quantitation of Two-Dimensional Echocardiograms: recommendations for quantitation of the left ventricle by two-dimensional echocardiography.
Relationship between ivabradine treatment and cardiovascular outcomes in patients with stable coronary artery disease and left ventricular systolic dysfunction with limiting angina: a subgroup analysis of the randomized, controlled BEAUTIFUL trial.
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Neurological: Testing of cranial nerves reveals nerves intact.
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Treatment with digitalis, spironolactone, vasodilators, and amiodarone was allowed, but not required.
Carvedilol, a non-cardioselective vasodilating beta-blocker, is more effective in reducing portal pressure than propranolol; however, there have been no clinical studies assessing the efficacy of carvedilol in primary prophylaxis.
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Furthermore, a long follow-up period may not be possible if the finding of a large treatment effect leads the Data and Safety Monitoring Board to recommend early termination of a study, as occurred in this case; the mean duration of follow-up in the present program was similar to that in other trials that have been terminated early.
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This finding has important implications for the design of future clinical trials.
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